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During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates and intravenous nitrogen-containing bisphosphonates circulate around the body the same way as the phosphorous vapors, and are absorbed into bone and ingested by osteoclasts. When this unique binding process of bisphosphonates to bone occurs, osteoclasts are poisoned, and this reduces or eliminates bone turnover. Alveolar bone in the mandible and maxilla turns over more rapidly than in long bones, so the jaws are a better target for bisphosphonate toxicity. It wasn't until 2003 that today's intravenous and oral nitrogen-containing bisphosphonate medications were implicated as major risk factors in the development of exposed necrotic bone of the jaws. Most of the researchers who reported cases of bisphosphonate-induced osteonecrosis of the jaw found that these patients were treated with zoledronate, pamidronate, or a combination of these drugs, which are commonly used for treating breast cancer or myeloma. In about 5% of cases, subjects with BIONJ were being treated for osteoporosis. Precipitating events that contribute to BIONJ are tooth extractions (about 50% of cases), mandibular exostoses, periodontal disease, and local trauma from ill-fitting dentures. It is not known if the placement of dental implants is a precipitating factor. The book aims to meet the need of medical practitioners working in all fields that use bisphosphonates, and to present the conservative and surgical treatment methods currently in use. There will also be detailed information on the literature relating to dental implants in patients treated with bisphosphonates.
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Bisphosphonates and Osteonecrosis of the Jaw: A ~ Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach (English Edition) eBook: Francesco Saverio De Ponte: : Kindle-Shop
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Bisphosphonates and Osteonecrosis of the Jaw: A ~ Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach Francesco Saverio De Ponte (eds.) During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches.
Bisphosphonates and osteonecrosis of the jaw : a ~ Get this from a library! Bisphosphonates and osteonecrosis of the jaw : a multidisciplinary approach. [Francesco Saverio De Ponte;] -- Bisphosphonates are commonly prescribed to inhibit bone loss in patients with osteoporosis, as well as osteopenia, cancer, and Paget's disease of the bone. Recently, scientific literature has .
Bisphosphonates and Osteonecrosis of the Jaw: A ~ Read "Bisphosphonates and Osteonecrosis of the Jaw: A Multidisciplinary Approach" by available from Rakuten Kobo. During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads m.
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Bisphosphonates and Osteonecrosis of the Jaw: A ~ Bisphosphonates are commonly prescribed to inhibit bone loss in patients with osteoporosis, as well as osteopenia, cancer, and Paget's disease of the bone. Recently, scientific literature has addressed a possible relationship between bisphosphonates and osteonecrosis of the jaw (ONJ). It is important to note that though the risks for developing .
Osteonecrosis of the Jaw in Patients Receiving Intravenous ~ To identify potential risk factors for the development of osteonecrosis of the jaw (ONJ) in patients receiving bisphosphonates, we conducted a MEDLINE search. We identified 44 Englishâlanguage published case reports and case series describing 481 patients with bisphosphonateârelated ONJ. Our review of these reports indicated that ONJ occurs more frequently in patients receiving intravenous .
Medicationârelated osteonecrosis of the jaw associated ~ Monique Chalem, Adriana Medina, Ana Karina Sarmiento, Deyanira Gonzalez, Carlos Olarte, Edgar Pinilla, Jorge Paz, Noemi Casas, Maria Paula Vega, Edna Diaz, Therapeutic approach and management algorithms in medication-related osteonecrosis of the jaw (MONJ): recommendations of a multidisciplinary group of experts, Archives of Osteoporosis, 10.1007/s11657-020-00761-0, 15, 1, (2020).
Medication-Related Osteonecrosis of the Jaw: MASCC/ISOO ~ Medication-related osteonecrosis of the jaw (MRONJ) is defined as exposed bone or bone that can be probed through an intraoral or extra oral fistula(e) in the maxillofacial region and that does not heal within 8 weeks and that occurs in a patient who has received a bone-modifying agent (BMA) or an angiogenic inhibitor agent and has no history of head and neck radiation. 1,2 The condition may .
BisphosphonateâAssociated Osteonecrosis of the Jaw: Report ~ Monique Chalem, Adriana Medina, Ana Karina Sarmiento, Deyanira Gonzalez, Carlos Olarte, Edgar Pinilla, Jorge Paz, Noemi Casas, Maria Paula Vega, Edna Diaz, Therapeutic approach and management algorithms in medication-related osteonecrosis of the jaw (MONJ): recommendations of a multidisciplinary group of experts, Archives of Osteoporosis, 10.1007/s11657-020-00761-0, 15, 1, (2020).
Osteonecrosis of the jaws associated with the use of ~ Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004; 62(5):527-34 (ISSN: 0278-2391) Ruggiero SL; Mehrotra B; Rosenberg TJ; Engroff SL. PURPOSE: Bisphosphonates are widely used in the management of metastatic disease to the bone and in the treatment of osteoporosis. We were .
Bisphosphonate-associated osteonecrosis of the jaws ~ All study patients were evaluated at a multidisciplinary jaw osteonecrosis clinic between June and December 2005. We identified 13 cases, in 12 women and 1 man, with a mean age of 62.6 years .
Diagnosis and Management of Osteonecrosis of the Jaw: A ~ This work provides a systematic review of the literature from January 2003 to April 2014 pertaining to the incidence, pathophysiology, diagnosis, and treatment of osteonecrosis of the jaw (ONJ), and offers recommendations for its management based on multidisciplinary international consensus. ONJ is associated with oncologyâdose parenteral antiresorptive therapy of bisphosphonates (BP) and .
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Osteonecrosis of the jaw (ONJ): diagnosis and management ~ Osteonecrosis of the jaw (ONJ) has been associated with the use of aminobisphosphonates and denosumab. The vast majority (>90 %) of cases occur in the oncology patient population receiving high doses of intravenous bisphosphonates or subcutaneous denosumab. The incidence of ONJ in the osteoporosis patient population is very low and is estimated at 1â90 per 100,000 patient-years of exposure.